Enterovirus

Rhinovirus; HRV; HRVs; HEV; HEVs

Enterovirus

Related Products

The genus Enterovirus (EV) belonging to the Picornaviridae family comprises 13 species, of which seven are human viruses. Four of the species are: (1) EV-A such as coxsackievirus (CV)-A6, CV-A10, CV-A16 and EV-A71, (2) EV-B such as the CV-B viruses, echoviruses (ECHO) and CV-A9, (3) EV-C such as polioviruses (PV) and CV-A21, (4) EV-D such as EV-D68 and EV-D70. The other three species are rhinoviruses RV-A, RV-B and RV-C which comprised over 100 different numbered RVs. Infection with enteroviruses can cause numerous clinical conditions including poliomyelitis, meningitis and encephalitis, hand-foot-and-mouth disease, acute flaccid paralysis, diarrhea, myocarditis and respiratory illness.

Enteroviruses are small, nonenveloped, positive-sense, single-stranded RNA viruses with an icosahedral capsid. The genome of ∼7.5 kb encodes a single polyprotein that is autoprocessed into structural proteins (VP1, VP2, VP3, and VP4), nonstructural proteins (2A, 2B, 2C, 3A, 3B, 3C, and 3D), and several functional processing intermediates. The viral nonstructural proteins, particularly the protease 3C^pro and the RNA-dependent RNA polymerase 3D^pol, are attractive targets for antiviral drug development.

Enterovirus Inhibitors (55)

Enterovirus Related Products (57):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-146009

AL-470	Inhibitor
AL-470 is a potent antiviral agent with EC₅₀ values of 0.27, 0.63, and 0.35 µM against HIV-1, HIV-2, and EV-A71, respectively.

HY-19952S

Pleconaril-d₄	Inhibitor
Pleconaril-d₄ is deuterium labeled Pleconaril.

HY-W016407

Methyl 3,4-dihydroxyphenylacetate	Inhibitor
Methyl 3,4-dihydroxyphenylacetate is a potent enterovirus 71 (EV71) infection inhibitor. Methyl 3,4-dihydroxyphenylacetate inhibits EV71 replication in rhabdomyosarcoma (RD) cells.

HY-151926

Antiviral agent 24	Inhibitor	99.63%
Antiviral agent 24 is a potent antiviral agent with EC₅₀ values of 0.101, 19.9, 91.2 µM for EV71, CVA21, EV68, respectively. Antiviral agent 24 inhibits METTL3/METTL14 activity in a dose-dependent manner.

HY-P5843

Citrullinated LL-37 4cit	Inhibitor
Citrullinated LL-37 3cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 3cit lacks all antiviral activity at 10 μg/mL and retains some activity against HRV at 30 μg/mL. Citrullinated LL-37 3cit reduces the immunomodulatory activity of LL-37. Citrullinated LL-37 3cit shows a moderate loss in the ability to reduce HRV-induced CCL5 secretion.

HY-146226

Viral 2C protein inhibitor 1	Inhibitor
Viral 2C protein inhibitor 1 (compound 6aw) is a potent and broad-spectrum enterovirus antiviral agent, inhibiting viral 2C protein. Viral 2C protein inhibitor 1 inhibits multiple strains of EV-D68, EV-A71 and CVB3 with EC₅₀s of 0.1~3.6 µM, and exhibits high selectivity index and relatively low cytotoxicity.

HY-P5836

Citrullinated LL-37 1cit	Inhibitor
Citrullinated LL-37 1cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 1cit does not alter the antiviral effect of LL-37 toward human rhinovirus. Citrullinated LL-37 1cit shows antibacterial activity toward S. aureus. Citrullinated LL-37 1cit causes a reduction in the levels of IL-8, CCL5, and IL-6 mRNA induced by RV1B.

HY-106312A

Enviroxime	Inhibitor
Enviroxime (LY122772) is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses. Enviroxime blocks the replication of plus-strand viral RNA by targeting the viral 3A coding region. Enviroxime can be a useful tool for investigating the natural function of the 3A protein.

HY-100540A

(Rac)-Golgicide A	Inhibitor
(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1.Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species.

HY-145850

EV-A71-IN-1	Inhibitor
EV-A71-IN-1 is a human enterovirus A71 (EV-A71) capsid protein inhibitor with an EC₅₀ of 0.27 μM against EV-A71. EV-A71-IN-1 is a capsid binder that blocks the interaction between the viral VP1 and the host receptor hSCARB2. EV-A71-IN-1 inhibits a series of different human enteroviruses without significant cytotoxicity (CC₅₀>56.2 μM).

HY-100679A

Pirlindole mesylate	Inhibitor
Pirlindole mesylate is a selective and reversible MAO-A inhibitor. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3) .

HY-147700

Antiviral agent 21	Inhibitor
Antiviral agent 21 (Compound 4) is an anti-EV71 agent.

HY-B0154S

Fluticasone propionate-d₃	Inhibitor
Fluticasone propionate-d₃ is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].

HY-101064S4

Fmoc-leucine-¹⁵N	Inhibitor
Fmoc-leucine-¹⁵N is a ¹⁵N-labeled and ¹³C-labled EIDD-1931. EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine ence

HY-100679S

Pirlindole-d₄
Pirlindole-d₄ is the deuterium labeled Pirlindole[1].

HY-125033S1

EIDD-1931-d₂
EIDD-1931-d2 is the deuterium labeled 3,6-Dichloro-2-methoxybenzoic acid.

HY-157082

ZHSI-1	Inhibitor
ZHSI-1 is an EV71 (Enterovirus 71) inhibitor that inhibits EV71/CVA16 replication and virus-induced pyroptosis associated with viral pathogenesis. ZHSI-1 effectively prevents EV71 infection in neonatal and young mice in animal models. ZHSI-1 can be used to study viral infections such as hand, foot and mouth disease (HFMD).

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